home remedies for diabetes

☀Natural Treatments☀ >> home remedies for diabetes 05 Jul 2020 Natural Remedies For [Home Remedies For]. [home remedies for diabetes] ☀☀Best Treatment√√√ home remedies for diabetes [☀☀Can Diabetes Be Cured Naturally?☀☀].

home remedies for diabetes Blood sugar disturbances, including high blood sugar and low blood sugar, are already included as a warning in most fluoroquinolone drug ...{Hypoglycemia is a condition caused by low blood glucose (blood sugar) levels. Glucose is the main way your body gets energy. The condition ...Most people feel symptoms of hypoglycemia when their blood sugar is 70 milligrams per deciliter (mg/dL) or lower. Each person with diabetes ...|Low blood sugar, also known as hypoglycemia, can be a dangerous condition. Low blood sugar can happen in people with diabetes who take ...|Hypoglycemia is a condition in which your blood sugar (glucose) level is lower than normal. Glucose is your body's main energy source.|Hypoglycemia is the medical term for low blood sugar. ... The normal range of blood glucose is from 70 to 100 mg/dL in an individual without diabetes, Most people will feel the effects and symptoms of low blood sugar when blood glucose levels are lower than 50 mg/dL.|Low blood sugar (also known as hypoglycemia) is when your blood sugar levels have fallen low enough that you need to take action to bring them back to your ...|Signs of low blood sugar include hunger, trembling, heart racing, nausea, and sweating. In severe cases, it can lead to coma and death. Hypoglycemia can occur with several conditions, but it most commonly happens as a reaction to medications, such as insulin. People with diabetes use insulin to treat high blood sugar.|Hypoglycemia occurs when blood sugar levels drop below 70 milligrams per deciliter (mg/dl). ... In people with diabetes, taking too much insulin can cause blood sugar levels to drop too low. Not eating enough or exercising too much after taking insulin can have the same effect.|The medical name of low blood sugar is hypoglycemia. Causes. Expand Section. Insulin is a hormone made by ...|What is Low Blood Sugar?|What You Can Do. Most of the sugar or glucose in your blood comes from carbohydrates. Carbohydrates are the sugars and starches in grains, beans, vegetables, ...|Hypoglycemia, also called low blood glucose or low blood sugar, occurs when the level of glucose in your blood drops below normal. For many people with ...|Signs of low blood sugar at night. If your blood sugar drops while you are sleeping, your partner or other family members may notice that you are sweating and ...|Low blood sugar, called hypoglycemia, happens when the level of sugar in the blood falls below 70 mg/dl. Blood sugar drops when there is more ...|Hypoglycemia is the condition when your blood glucose (sugar) levels are too low. It happens to people with diabetes when they have a ...|If your blood sugar level drops just slightly below your target range (mild low blood sugar), you may feel tired, anxious, weak, shaky, or sweaty, and you may have ...|If you start feeling confused or disoriented or have trouble walking or seeing, you may have very low blood sugar. If you're not able to test your blood glucose ...|Treating Low Blood Sugar. Related Conditions. Diabetes Mellitus. You ...|Hypoglycemia is low blood glucose (sugar), usually less than 70 mg/dl (although you and your health care provider may come up with a different number).|At some time, most people with diabetes experience the sweating and shakiness that occurs when blood glucose levels fall below 70 mg/dl — a condition known ...|Hypoglycemia, or low blood sugar, occurs when a diabetic has not eaten enough food, or has too much insulin within his or her body. An ...|Symptoms of mild low blood sugar You may have these symptoms when your blood sugar has dropped below 70 milligrams per deciliter (mg/dL). When you ...|Symptoms of Hypoglycemia: You may feel sweaty, shaky or hungry. You may feel faint. Extremely low blood sugar levels may cause you to be confused, ...|Hypoglycemia, also known as low blood sugar, is a fall in blood sugar to levels below normal. This may result in a variety of symptoms including clumsiness, ...|10 Warning Signs of Low Blood Sugar. Hypoglycemia can cause both short- and long-term complications. Know the signs so that you can treat ...|Low blood sugar (glucose), is called hypoglycemia (hypo = low + glyc = sugar + emia = in the blood). Hypoglycemia is caused by many different conditions and ...|Want to lower your blood sugar? Learn to better control your glucose levels by preventing blood sugar spikes and swings to avoid neuropathy ...|Hypoglycemia occurs when the level of sugar in the blood is too low. It can also be called insulin shock or insulin reaction. Hypoglycemia is when the level of ...|Hypoglycemia is a serious condition that happens when your blood glucose (sugar) level drops too low. The blood sugar level is usually too ...|When blood sugar drops below 70 mg/dL, it is a signal that the body is becoming ... Not being aware of low blood-sugar levels is a particularly ...|But some people with diabetes also are at risk for blood sugar to swing in the opposite direction and dip far too low, triggering a dangerous ...|Low blood sugar can happen if you are taking insulin for your diabetes. It is important to know what can cause low blood sugar and how to treat it. You can ...|You might get low blood sugar (also called hypoglycemia) if you: • Take certain medicines and eat too few carbohydrates. • Skip or delay meals. • Take too much ...|If their blood sugar is low enough, they may not be able to process the question. You can try to get them to eat or drink something to slowly raise it.|The importance of preventing low blood sugar (hypoglycemia) in newly diagnosed people with type 1 diabetes is #1. Check blood sugar and eat a healthy diet.|When blood sugar levels fall too low, the body releases the hormone adrenaline, which helps get stored glucose into the bloodstream quickly. Paleness, sweating, ...|At some point everyone will have a low blood sugar. If you can, test first to confirm low BG. Treat with 15gms fast acting carbohydrate (1/2 cup juice or regular soda ...|Usually, a blood sugar level of less than 70 mg/dL is considered too low and needs to be treated. Anything that lowers your blood sugar can cause.|Hypoglycemia, on the other hand, is when your fasting glucose is low. Hypoglycemia is a very unusual event and is usually caused by a tumor that produces too ...|Hypoglycaemia is an abnormally low level of glucose in your blood (less than four millimoles per litre). Learn about its symptoms and treatment.|Hypoglycemia is the state of having a blood glucose level that is too low to effectively fuel the body's cells. Glucose, which comes from carbohydrates found in ...|Low blood sugar, a.k.a. hypoglycemia, happens when the level of glucose in your blood drops below normal, according to the National ...|Hypoglycemia (low blood sugar) occurs when your blood sugar (glucose) levels are less than or equal to 70 mg/dL and symptoms are present.|In people who do not have diabetes, low blood sugar can be caused by a variety of factors, including alcohol consumption, infections and some medications or ...|Hypoglycemia, also known as low blood sugar, occurs when levels of glucose (sugar) in the blood are too low. Hypoglycemia is common in ...|Juice is my preferred method of treating a low when my blood sugar levels have gone below 70 mg/dL and are trending low. I prefer this method ...|In hypoglycemia, the glucose level becomes too low. Although diabetes mellitus, a disorder involving blood glucose levels, is characterized by high levels of ...|Insulin and exercise both lower blood sugar and food raises it. Hypoglycemia is common in people who are taking insulin or oral medications that ...|Most students can tell when their blood sugar is low; however, a low level can occur with little warning. Causes. Too much insulin in the body; Meals and snacks ...|Hypoglycemia is the term for low blood sugar (or blood glucose). Glucose is the “fuel” that your brain and body need to function properly.|Discusses hypoglycemia (low blood sugar) in people who don't have diabetes. Explains blood sugar (glucose) in the body. Describes symptoms of mild, ...|Hypoglycemia occurs when the levels of glucose (sugar) in your blood are too low. It is a complication that can affect people with diabetes, but it ...|If you check your blood sugars, these are the desired blood sugar ranges to aim for. Also included in this handout is a list of signs and symptoms ...|What is low blood sugar? Blood sugar is considered to be too low if it is lower than 70 milligrams per deciliter (mg/dL), or 4 millimoles per liter (mmol/L). If low ...|Hypoglycemia most often affects those at the extremes of age, such as infants and the elderly, but may happen at any age. Generally, hypoglycemia is defined as a ...|Very low blood sugar can cause fatigue, dizziness, headache, visual disturbances, drowsiness and ultimately loss of consciousness and seizures ...|Low blood sugar, or hypoglycemia occurs when blood sugar levels drop lower than where they should be. Some people may refer to this as a ...|Low blood sugar, also called hypoglycemia, occurs when your blood sugar gets below 70 mg/dL. When this happens, you can consume sugary foods or drinks ...|Blood sugar disturbances, including high blood sugar and low blood sugar, are already included as a warning in most fluoroquinolone drug ...|Significantly, the most common problem diabetics experience today is not “high blood sugar” but “low blood sugar!” Diabetes medications are powerful but ...|Low blood sugar occurs when the sugar (glucose) level in your blood drops below what your body needs. Not eating enough food or skipping ...|You may recognize the feeling—feeling hungry, dizzy, sweaty or just a little bit "off." These signs of hypoglycemia, or low blood glucose, mean it's time to take ...|Low blood sugar, known as hypoglycemia, occurs in 20 to 60 percent of patients with diabetes. It has substantial negative effects on a person's ...|Irritability/Confusion; Fainting. Causes of low blood sugar include: Too much insulin or too many diabetes pills; Not enough food or missing a meal ...|Which drugs increase the risk of hypoglycemia (low blood sugar)?. Updated: Sep 12, 2019. Author: Osama Hamdy, MD, PhD; Chief Editor: Romesh Khardori, ...|Having frequent low blood sugar can trick your body into thinking hypoglycemia is normal. Without symptoms like tremors, headaches, or ...|Medicines that can cause drug-induced low blood sugar include: Bactrim (an antibiotic); Beta-blockers; Haloperidol; Insulin; MAO inhibitors ...|Saudek answers the question: 'How to Recognize/Treat Low Blood Sugar?' By. Christopher D. Saudek, M.D., Hugh P. McCormick Family ...|Alcohol can reduce the amount of glucose produced by the liver and can put you at risk for a low blood sugar. The solution: Drink alcohol in moderation. Eat ...|In people with type 1 and type 2 diabetes, low blood sugars are generally caused by an imbalance of food, activity, and insulin — or other ...|In this article, we will explore what low blood sugar feels like for different people with diabetes. We will look at the symptoms, how they can ...|Hypoglycemia happens when your blood glucose levels have fallen low enough that you need to take action to bring them back to your target ...|If you have diabetes, you don't just need to watch out for high blood sugar but low blood sugar (also known ...|One danger of low blood sugar (hypoglycemia) is that you might not know you're having it. Low glucose levels affect your brain.|A low blood sugar, also called hypoglycemia or an insulin reaction, is defined as a blood glucose level below 60 to 70 mg/dl. It is usually companied by one or ...|What are the symptoms of low blood sugar? Watch for these early signs of low blood sugar: • You have nausea. • You are hungry.|If your blood sugar drops low enough that you need help to recover, it is considered to be a low blood sugar emergency, or severe hypoglycemia. Mild or moderate ...|What causes blood sugar to be high or low? What are ketones, ketosis, and ketoacidosis? How do carbs affect blood sugar levels? What else ...|If your blood sugar is still less than 70 mg/dL when you retest, take another 15 grams of sugar. Retest 15 minutes later. Keep doing this until your ...|Symptoms of low blood sugar. A low blood sugar causes different symptoms for everybody. You'll learn how it makes you feel if you keep getting it, although your ...

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.

home remedies for diabetes 🔥how to home remedies for diabetes for Benzie IFF, Wachtel-Galor S, editors. Herbal Medicine: Biomolecular and Clinical Aspects. 2nd edition. Boca Raton (FL): CRC Press/Taylor & Francis; 2011.

Herbal Medicine: Biomolecular and Clinical Aspects. 2nd edition.

Show details
Benzie IFF, Wachtel-Galor S, editors.
Boca Raton (FL): CRC Press/Taylor & Francis; 2011.

William T. Cefalu, Jaqueline M. Stephens, and David M. Ribnicky.

19.1. INTRODUCTION

The epidemic rise in the number of new cases of diabetes is one of the most alarming statistics regarding health issues on a worldwide basis. The major concern regarding this observation relates to the development of the chronic complications associated with the condition. Specifically, the complications of diabetes have been classified as either microvascular—retinopathy, nephropathy, and neuropathy—or macrovascular—cardiovascular disease (CVD), cerebrovascular accidents (CVA), and peripheral vascular disease (PVD). It is well recognized that the complications cause considerable morbidity and mortality worldwide and, as such, negatively affect the quality of life in individuals with diabetes, with an increase in disability and death. The costs of caring for diabetes and its related complications are staggering. For example, in the United States alone, the total estimated financial burden of diabetes was US$174 billion in 2007, and it is expected to be US$330 billion by 2020 due to the expected increase in new cases.

In an individual with diabetes, on a clinical level the major objective is to design a regimen that will improve the metabolic factors associated with the development and progression of complications. As such, it is well recognized that a primary strategy is to achieve the target levels recommended for blood pressure, lipids, and glycemia. This strategy may consist of lifestyle modification alone, but more commonly it consists of lifestyle management, that is, dietary modification and enhanced physical activity, combined with pharmacological intervention from agents in multiple classes (Riddle 2005). However, as providers caring for patients with diabetes, we recognize that the patients are very interested in alternative (complementary) strategies that consist of dietary supplementation with over-the-counter agents. Supplementing conventional approaches to medical care with alternative means is extensively practiced by a large number of patients. Interestingly, more times than not, these practices appear to be undertaken without consultation with a medical provider. It is also recognized that this is not a trivial practice and not without substantial financial cost. Specifically, data from the Food and Drug Administration (FDA) of the United States suggest that more than 29,000 different nutritional supplements are available to consumers. It also appears that more than US$12 billion per year may be spent on supplements (Neuhouser 2003; Gibson and Taylor 2005).

Patients may choose to supplement their pharmacological regimen with dietary supplementation in many forms, for example, vitamin and/or mineral mixtures, but the most popular supplements taken by the patients are those considered to be from natural products, that is, herbal or botanical sources. Unfortunately, considerable controversy exists regarding the efficacy of dietary supplements in general and of botanical supplements, particularly regarding pathophysiological factors related to the treatment of patients with type 2 diabetes. The controversy exists because reported efficacy data for many of the natural products are only in the form of uncontrolled studies and anecdotal reports. Poor quality control measures may also cause inconsistent effects for certain natural products. Currently, there is a paucity of consistent and reproducible efficacy data in humans to suggest any recommendations for most botanical or bioactive supplements as adjunct treatments for risk factors related to metabolic syndrome or type 2 diabetes. Firm recommendations for general use would also require an understanding of the mechanism of action, which is not known for most botanicals.

19.2. HISTORICAL USE OF BOTANICALS

From the patient perspective, it is considered very acceptable to include herbal or botanical extracts as part of the medical intervention based on the recognition that the herbal intervention is considered to be natural and that the practice may have been part of the culture for many generations. In this regard, the use of plants and plant extracts to treat a specific disease and/or disease symptoms appears to have been part of medical care as observed for thousands of years. Although the use of plant extracts is no longer a major aspect of medical care as practiced in Western populations, it is still extremely popular in large numbers of the world’s population, particularly in Asia and Europe (Griggs 1981). However, for medicine as practiced in Western countries, one observation that appears to be forgotten is that many of the pharmaceutical agents currently prescribed appear to have been derived from natural compounds found in traditional medicinal plants (Evans 2003). As a specific example, biguanide metformin is considered one of the first-line agents used for the treatment of type 2 diabetes, and its use can be traced to the traditional use of Galega officinalis to treat diabetes and the subsequent search to identify active compounds with reduced toxicity (Cusi and Defronzo 1998). However, it has been reported that more than 1200 traditional plants may have been used for real or perceived benefit of medicinal purposes for the treatment of diabetes (Marles and Farnsworth 1995; Jung et al. 2006). In this regard, the reader is referred to a number of published reviews on the topic that contain information related to the following: (1) the botanical source of the extract; (2) the history of use by the population; (3) the specific geographic region in the world for which its use has been documented; (4) the proposed benefit of the extract; (5) known side effects; and (6) proposed mechanisms of action (Griggs 1981; Marles and Farnsworth 1995; Roman-Ramos, Flores-Saenz, and Alarcon-Aguilar 1995; Oubre et al. 1997; Dey, Attele, and Yuan 2002; Grover, Yadov and Yats 2002; Shapiro and Gong 2002; Evans 2003; Jung et al. 2006).

19.3. PROPOSED MECHANISMS OF BOTANICAL ACTIONS

Despite the historical use of botanicals to treat diabetes and its related symptoms, one of the major concerns for this area of study is the paucity of definitive and consistent data on efficacy, and more importantly, a lack of knowledge about precise mechanism(s) of action. These are significant limitations, and in large part these limitations explain why there is considerable skepticism regarding the effectiveness of herbal remedies in Western medicine. However, there is growing evidence in this area, and if a botanical is demonstrated to have a favorable effect on a given mechanism, that will provide the rationale for further and more definitive studies on a particular botanical.

The physiological parameters that regulate glucose metabolism and the pathophysiological changes that occur and that give rise to diabetes have been studied for years. These involve the interplay and function of multiple peripheral tissues, such as liver, muscle, and adipose tissue. In order to exert an effect, botanicals may theoretically modulate glucose at several different levels in multiple tissues (Table 19.1; Cefalu and Ribnicky 2009). Thus, based on reported abnormalities for type 2 diabetes, botanicals could be proposed to affect the whole-body metabolism by modulating adipocyte function and thus, regulating endocrine secretions that play a role to enhance the skeletal muscle insulin action. In addition, based on the known abnormalities, botanicals may regulate hepatic processes, that is, hepatic gluconeogenesis, and may affect the whole-body glucose levels. In this regard, a specific agent termed a “biguanide” (metformin) and derived from botanical sources appears to improve hyperglycemia by regulating hepatic processes. Type 2 diabetes is clearly a disorder that involves insulin secretory defects, and enhancing pancreatic β-cell function is another proposed pathway by which botanicals may theoretically work. Enhancing insulin secretory function may not be solely an acute effect. But as intensively pursued in preclinical and clinical trials, if a particular agent is shown to enhance proliferation and/or modulate apoptosis of islet tissue, this may markedly impact the natural progression of diabetes. There is no evidence to date that any of these postulated effects are consistently noted with any botanical supplement presently available. Finally, another postulated pathway by which botanicals may work is by direct regulation of insulin action in peripheral tissues such as skeletal muscle and adipose tissue. In this regard, there is evidence to support the botanical modulation of these processes.

TABLE 19.1

Postulated Mechanisms by Which Botanicals May Alter Whole-Body Carbohydrate Metabolism.

19.4. INSULIN RESISTANCE IN TYPE 2 DIABETES

One of the major abnormalities in obesity and type 2 diabetes is insulin resistance. Insulin resistance has been shown to be present in prediabetes, and at this stage of the natural history of diabetes, insulin secretion is observed to be increased, that is, hyperinsulinemia, in order to compensate for the insulin resistance. Given the compensation, glucose levels remain at or near the normal level. However, when insulin secretory function begins to decline, full compensation of insulin resistance is not observed, and hyperglycemia is noted at that time. Clearly, insulin resistance is a key pathophysiological feature of type 2 diabetes and is strongly associated with cardiovascular risk factors and accelerated atherosclerosis. Given the central role of insulin resistance to diabetes, one of the most desirable goals of treatment for subjects with type 2 diabetes is directed at increasing the insulin sensitivity in vivo. Caloric restriction and enhanced physical activity are well known to enhance insulin sensitivity. Unfortunately, maintenance of lifestyle intervention for patients is difficult in the long term. Therefore, a very attractive approach to improve the insulin sensitivity has been proposed with the use of botanical supplementation.

Insulin action in peripheral tissues, such as adipose tissue and muscle, involves receptor binding and enhanced intracellular signaling. The initial step is the binding of insulin to the α-subunit of its receptor. This binding leads to autophosphorylation of specific tyrosine residues of the β-subunit and enhanced tyrosine kinase activity of the receptor toward other protein substrates (Cefalu 2001; Figure 19.1). Enhanced insulin receptor tyrosine kinase activation results in tyrosine phosphorylation of insulin receptor substrates, activation of PI-3 kinase, and the resulting cellular processes associated with insulin action (glucose transport, GLUT-4 translocation, glycogen synthesis, protein synthesis, antilipolysis, and gene expression; Cefalu 2001). On theoretical grounds, a botanical may be capable of altering insulin action by modulating any of the steps in the insulin receptor signaling cascade.

FIGURE 19.1

The insulin signaling cascade. (From Cefalu, W. T. 2001. Exp Biol Med (Maywood) 226:13–26. With permission.)

19.5. BOTANICALS AND MECHANISMS RELEVANT TO TYPE 2 DIABETES

A limited list of selected botanicals that are reported to alter carbohydrate metabolism is given in Table 19.2. However, it is important to note that consistent documentation of a glucose- or insulin-lowering effects has not yet been shown for any specific botanical. Each botanical having historical use, current use in herbal supplements, or potential for clinical efficacy based on proposed mechanisms is briefly described in Sections 19.5.1 through 19.5.12.

home remedies for diabetes ☑how to home remedies for diabetes for TABLE 19.2

Selected Botanical Therapeutics and Proposed Action on Carbohydrate Metabolism.

19.5.1. B for 1 last update 2020/07/05 itteritter Melon (Momordica charantia)

Bitter melon is a traditional plant of Asian origin that has been a popular botanical proposed for treatment of diabetes and diabetes-related complications (Leung et al. 2009). The mechanism of action is believed to be secondary to multiple bioactives, one of which, polypeptide-p, is reported to have a structure similar to insulin as found in animals, and as the 1 last update 2020/07/05 such, is proposed to have glucose-lowering effects (Basch, Gabardi, and Ulbricht 2003; Evans 2003; Grover and Yadav 2004; Krawinkel and Keding 2006). Specifically, bitter melon fruit contains cucurbitane-type triterpenoids, steroidal saponins called “charantins,” insulinlike peptides, and alkaloids, which are postulated to have effects on carbohydrate metabolism (Leung et al. 2009). As reported, clinical results with the use of bitter melon are inconsistent, as only about half the studies demonstrate efficacy. Clearly, there is controversy regarding the reported observations, and there are concerns with study design and the adequacy of statistical analyses.Bitter melon is a traditional plant of Asian origin that has been a popular botanical proposed for treatment of diabetes and diabetes-related complications (Leung et al. 2009). The mechanism of action is believed to be secondary to multiple bioactives, one of which, polypeptide-p, is reported to have a structure similar to insulin as found in animals, and as such, is proposed to have glucose-lowering effects (Basch, Gabardi, and Ulbricht 2003; Evans 2003; Grover and Yadav 2004; Krawinkel and Keding 2006). Specifically, bitter melon fruit contains cucurbitane-type triterpenoids, steroidal saponins called “charantins,” insulinlike peptides, and alkaloids, which are postulated to have effects on carbohydrate metabolism (Leung et al. 2009). As reported, clinical results with the use of bitter melon are inconsistent, as only about half the studies demonstrate efficacy. Clearly, there is controversy regarding the reported observations, and there are concerns with study design and the adequacy of statistical analyses.

home remedies for diabetes 🔥how to home remedies for diabetes for Another variable that may contribute to inconsistent results is the preparation of the test material. Test material is comprised of fresh juice, dried whole fruit, fresh fruit, dried seedless fruit, seeds, aqueous extract, methanolic extract, or tablets (Ahmad et al. 1999; Rathi, Grover, and Vats 2002; Grover and Yadav 2004; Leung et al. 2009). Such variation would greatly affect the bioactive content of the preparation and the bioavailability of the active compounds. Ahmad et al. (1999) reported on a relatively large (n = 100) intervention study with freshly prepared bitter melon fruit given to type 2 diabetic patients after a 3-day washout period of oral medications. The investigators reported an overall decrease in fasting glucose and postprandial glucose (Ahmad et al. 1999). Other data have suggested the beneficial effects of bitter melon for related complications of diabetes, such as renal for 1 last update 2020/07/05 disease, neuropathy, gastrointestinal disturbances, and ophthalmologic complications, that is, cataracts, in addition to a possible beneficial effect on dyslipidemia (Ahmed et al. 2001; Grover et al. 2001; Grover, Yadav, and Vats 2002; Grover, Rathi, and Vats 2002; Rathi et al. 2002; Chaturvedi 2005; Fernandes et al. 2007).Another variable that may contribute to inconsistent results is the preparation of the test material. Test material is comprised of fresh juice, dried whole fruit, fresh fruit, dried seedless fruit, seeds, aqueous extract, methanolic extract, or tablets (Ahmad et al. 1999; Rathi, Grover, and Vats 2002; Grover and Yadav 2004; Leung et al. 2009). Such variation would greatly affect the bioactive content of the preparation and the bioavailability of the active compounds. Ahmad et al. (1999) reported on a relatively large (n = 100) intervention study with freshly prepared bitter melon fruit given to type 2 diabetic patients after a 3-day washout period of oral medications. The investigators reported an overall decrease in fasting glucose and postprandial glucose (Ahmad et al. 1999). Other data have suggested the beneficial effects of bitter melon for related complications of diabetes, such as renal disease, neuropathy, gastrointestinal disturbances, and ophthalmologic complications, that is, cataracts, in addition to a possible beneficial effect on dyslipidemia (Ahmed et al. 2001; Grover et al. 2001; Grover, Yadav, and Vats 2002; Grover, Rathi, and Vats 2002; Rathi et al. 2002; Chaturvedi 2005; Fernandes et al. 2007).

19.5.2. Fenugreek (Trigonella foenum-graecum)

Fenugreek has a long and storied history of medicinal use and has been used worldwide for the treatment of diabetes (Basch et al. 2003; Evans 2003). Specifically, fenugreek is described as for 1 last update 2020/07/05 a leguminous herb that is cultivated in India and North Africa. The seeds are used as a food ingredient and spice, and they are reported to contain high amounts of protein and fiber. Fenugreek is reported to have hypoglycemic and hypocholesterolemic actions in both animal and human studies (Srinivasan 2006). The clinical effects of fenugreek, and particularly, the hypoglycemic effects, may be secondary to the fiber content, which potentially may affect gastric emptying and may result in a decrease in postprandial blood glucose levels. Many other bioactive compounds, such as the alkaloid trigonel-line and steroidal saponins, have been reported. 4-hydroxyisoleucine is considered to be an active compound in fenugreek and reportedly has an insulinlike effect (Broca et al. 1999, 2000).Fenugreek has a long and storied history of medicinal use and has been used worldwide for the treatment of diabetes (Basch et al. 2003; Evans 2003). Specifically, fenugreek is described as a leguminous herb that is cultivated in India and North Africa. The seeds are used as a food ingredient and spice, and they are reported to contain high amounts of protein and fiber. Fenugreek is reported to have hypoglycemic and hypocholesterolemic actions in both animal and human studies (Srinivasan 2006). The clinical effects of fenugreek, and particularly, the hypoglycemic effects, may be secondary to the fiber content, which potentially may affect gastric emptying and may result in a decrease in postprandial blood glucose levels. Many other bioactive compounds, such as the alkaloid trigonel-line and steroidal saponins, have been reported. 4-hydroxyisoleucine is considered to be an active compound in fenugreek and reportedly has an insulinlike effect (Broca et al. 1999, 2000).

home remedies for diabetes ☑how to home remedies for diabetes for As noted with several herbal preparations, inconsistent clinical results also have been observed with fenugreek that may have resulted from inadequate study design, lack of precise end points, underpowered studies, or variability in the test substance. However, fenugreek seed powder has been reported to favorably affect the glycemic index of food and glucose tolerance in both control and diabetic subjects (Gopalpura, Jayanthi, and Dubey 2009). Additional studies have suggested that treatment of diabetic subjects for 8 weeks resulted in improvements in fasting glucose and dyslipidemia (triglycerides; Kassaian et al. 2009). Interestingly, more consistent results are obtained when fenugreek is provided at larger doses of 10–20 g/day, and this may be related to an effect on digestive processes (Srinivasan 2006).

19.5.3. G for 1 last update 2020/07/05 ymnemaymnema (Gymnema sylvestre)

Gymnema sylvestre, known as gurmar, is native to Africa, Middle East, and India, and it has historical use in the treatment of diabetes and is commonly used (Grover, Yadov, and Vats 2002). The gymnema leaf or its extract is reported to be the most commonly used preparation of the plant. Potential antidiabetic compounds include oleanane triterpenoid saponins (i.e., gymnemic acids), dammarane saponins called gymnemosides, and a polypeptide called gurmarin (Porchezhian and Dobriyal 2003). There are extensive studies in animal models. Particularly, the effect of Gymnema sylvestre extract on carbohydrate metabolism has been suggested to be secondary to improving glucose uptake in peripheral tissues and increasing insulin secretion and β cell number in the pancreas (Dey, Attele, and Yuan 2002). However, there has been a paucity of definitive clinical studies that would allow one to provide clear guidelines on efficacy and safety (Leach 2007). In addition to the proposed systemic hypoglycemic activity in vivo, gymnema preparations are postulated to suppress the taste sensation of sweet, decrease the uptake of glucose from the small intestine, improve glucose metabolism, decrease HbA1c, and improve insulin secretion and dyslipidemia (Baskaran et al. 1990; Porchezhian and Dobriyal 2003; Ramkumar et al. 2008; Daisy, Eliza, and Mohamed Farook 2009). Clearly, completion of well-designed clinical studies is needed before definitive recommendations can be made for Gymnema.

19.5.4. Hhome remedies for diabetes ⭐️how to home remedies for diabetes for oodia (Hoodia gordonii)

The prevalence and incidence of obesity worldwide have reached epidemic proportions. Specifically, obesity is a key pathophysiological feature that contributes to the development of the metabolic syndrome and type 2 diabetes. In general, lifestyle modifications such as dietary restriction and enhanced physical activity are very effective in promoting weight loss and decreasing rates of progression of metabolic syndrome to type 2 diabetes (Knowler et al. 2002). However, lifestyle modifications alone are rarely sustained over a long-term period. Thus, a botanical that effectively alters energy balance, that is, increasing energy expenditure or lowering energy intake, would be of great interest to public health. In this regard, hoodia is currently marketed as an appetite suppressant component of many diet products. Data suggest that the botanical appears to have an anorexic effect in preclinical studies, and a steroidal pregnane glycoside (P57AS3) has been purified from the plant and is suggested to be the responsible anorexic compound (MacLean and Luo 2004). However, there are more than 30 pregnane glycosides identified from hoodia, all of which potentially could contribute to the overall clinical effect (Shukla et al. 2009). Nonetheless, it is important to note that there is no published or definitive clinical evidence demonstrating that hoodia does effectively reduce appetite. There is another concern that relates to the adulteration of hoodia products currently available on the market (Avula et al. 2008).

19.5.5. Prickly Pear Cactus (Opuntia spp.)

Prickly pear is a common cactus, and its fleshy stems and pearlike fruits are consumed as both medicine and food. It is a widely known and a commonly used herbal treatment for glucose control in Central and South America (Roman-Ramos, Flores-Saenz, and Alarcon-Aguilar 1995; Evans 2003). Prickly pear cactus is reported to have a very high-soluble fiber and pectin content that may prevent the absorption of sugars (Marles and Farnsworth 1995). This may be the most likely reason for regulatory effects on blood glucose on a whole-body level, but other mechanisms also have been suggested (Marles and Farnsworth 1995; Roman-Ramos, Flores-Saenz, and Alarcon-Aguilar 1995; Evans 2003). Isorhamnetic-3-glucoside is reported to be one of the many active flavonoids isolated from Opuntia (Ginestra et al. 2009). In preclinical studies, Opuntia spp., pectin, seed oil, and powder significantly lowered total cholesterol, low-density lipoprotein (LDL)-cholesterol, and triglyceride levels (Fernandez et al. 1992; Li et al. 2005; Ennouri et al. 2006; Oh and Lim 2006). Favorable effects on dyslipidemia were confirmed in a pilot study of 24 nondiabetic male subjects. Specifically, Opuntia robusta pectin lowered total cholesterol by 12%, LDL cholesterol by 15%, triglycerides by 12%, blood glucose by 11%, and insulin levels by 11% (Wolfram et al. 2002). Two controlled short-term studies of 14 and 22 human subjects, respectively, reported decreased fasting glucose and insulin levels in patients with type 2 diabetes (Frati et al. 1990; El Kossori et al. 1998).

19.5.6. G for 1 last update 2020/07/05 insenginseng (Panax spp.)

Ginseng has been a very popular botanical that has been suggested to control diabetes (Griggs 1981; Marles and Farnsworth 1995; Vogler, Pittler, and Ernst 1999; Evans 2003). A review of controlled trials (Vogler, Pittler, and Ernst 1999) using ginseng extracts (mostly Panax ginseng [Asian ginseng] and Panax quinquefolius [American ginseng]) concluded that there was insufficient evidence to support the efficacy for lipid or glycemic indications. Buettner et al. (2006) summarized a comprehensive database analysis of the reported studies of ginseng (Panax spp.) for efficacy related to cardiovascular risk factors, including blood pressure, lipid profiles, and blood glucose. The overall analysis suggested that ginseng was noted to slightly decrease blood pressure compared with placebo (range: 0–4%), but they observed mixed results for an effect on lipids. Furthermore, they found several studies showing that ginseng lowers blood glucose, but overall they concluded that the results were inconsistent (Buettner et al. 2006).

19.5.7. Cinnamon (Cinnamomum cassia, V the 1 last update 2020/07/05 erum, anderum, and Others)

Cinnamon has not only been used historically for the treatment of diabetes but is a supplement that is gaining in popularity, and many cinnamon products are currently available as dietary supplements. The bioactives considered to be responsible for antidiabetic effects are not precisely known, but polyphenol type-A polymers are believed to represent some of the active components of cinnamon that may have insulin-mimetic effects (Jarvill-Taylor, Anderson, and Graves 2001; Anderson et al. 2004). As such, there are data suggesting an effect in preclinical studies that have evaluated cinnamon in murine models of diabetes. There is a growing database of clinical studies on cinnamon, but similar to clinical results as observed with other herbal products, the results are not entirely consistent. Again, selection criteria of the cohort, clinical end points selected, appropriate dose, and source of cinnamon bioactives are all factors that potentially contribute to the variable clinical results (Dugoua et al. 2007). However, studies have suggested a positive effect in some settings. Specifically, Crawford (2009) evaluated 109 diabetic patients who were previously treated with diet and exercise. The intervention consisted of 1 g/day dose of cinnamon for 90 days and seemed to be effective to significantly lower antecedent glycemia, as assessed with HbA1c, in the treatment group relative to the control group. Other studies also suggested beneficial effects on glucose and lipids (Khan et al. 2003; Anderson 2008; Mang et al. 2006), whereas other investigations failed to reveal an effect on glycemia or lipids (Altschuler et al. 2007; Blevins et al. 2007). Other effects of cinnamon on cardiovascular risk factors such as antihypertensive effects have been suggested in preclinical and small clinical trials evaluating subjects with metabolic syndrome (Preuss et al. 2006; Ziegenfuss et al. 2006).

19.5.8. Russian Tarragon (Artemisia dracunculus L.)

Over the recent past, an ethanolic extract of Artemisia dracunculus L. (commonly known as Russian tarragon) has been demonstrated to have antidiabetic properties. Its antidiabetic effects were shown in several preclinical studies evaluating both chemically induced (i.e., streptozotocin-induced) and genetically diabetic (i.e., KK-A(y) mice) murine models (Ribnicky et al. 2006). Bioactives that have been identified as part of the extract include 4,5-di-O-caffeolquinic acid, davidigenin, 6-demethoxycapillarison, and 2′, 4′-dihydroxy-4-methoxydihydrochalcone as aldose reductase inhibitors (Logendra et al. 2006) and 2′, 4′-dihydroxy-4-methoxydihydrochalcone, 2′ 4-dihydroxy-4′-methoxydihydrochalcone, and sakuranetin as protein tyrosine phosphatase-1B inhibitors (Wang et al. 2008), whereas 6-demethoxycapillarisin and 2′, 4′-dihydroxy-4-methoxydihydrochalcone inhibited PEPCK gene expression in cultured liver cells (Govorko et al. 2007). Both in vitro and preclinical studies strongly suggest that the primary effect of the extract is to favorably affect insulin signaling in the muscle (Wang et al. 2008, 2010). The improved cellular signaling has been related to enhanced whole-body insulin sensitivity. A pilot human trial in a small number of insulinresistant subjects suggested that the alcoholic extract of Artemisia dracunculus L. enhanced insulin sensitivity in subjects randomized to the Artemisia extract compared to the baseline value, but it was not significantly changed compared to the placebo group. No changes in insulin sensitivity at the end of the study were noted compared to baseline in the placebo group. In addition, no changes in body weight or body fat composition between the treatment groups were observed. Of note, this pilot study was the first to show that specific bioactive compounds from the botanical extract of Artemisia dracunculus L. (i.e., davidigenin, chalcone, and sakuranetin) that had been noted to have significant effects in vitro from preclinical studies could be identified in the plasma of subjects after extract ingestion (Ribnicky et al. in press).

19.5.9. Garlic (Allium sativum)

Garlic is one of the more intriguing herbal remedies used historically. The range of beneficial effects of garlic is very broad and has been traditionally used as an antithrombotic, antihypertensive, cholesterol-lowering, antioxidant, antimutagenic, and antimicrobial agent. As would be expected for an herbal remedy proposed to have such broad effects, there has been a tremendous amount of research interest into its actions. In particular, a number of preclinical and clinical studies report the hypotensive effect of garlic, which appears to be more consistent in animal studies, as opposed to clinical studies (Ali et al. 2000; Sharifi, Darabi, and Akbarloo 2003; Cruz et al. 2007). The precise mechanism of action by which garlic lowers blood pressure is not known. However, it is proposed that garlic modulates endothelial production of nitric oxide (NO), inhibits angiotensin-converting enzyme (ACE) activity, decreases the production of vasoconstrictive agents thromboxane-B2 and prostaglandin-E2 and has potent free-radical scavenging activity (Al-Qattan et al. 2001; Ku et al. 2002; Sharifi, Darabi, and Akbarloo 2003; Medina-Campos et al. 2007). As with other herbal preparations, the variability in the clinical results may stem from differences in garlic preparations used for study or the specific content of bioactives represented in the preparation. Some bioactives have been reported to include unstable sulfur-containing compounds, polyphenols, flavonoids, anthocyanins, tannins, and others (Rahman and Lowe 2006; Chen et al. 2009).

A recent meta-analysis was conducted on clinical studies over the past half-century. The meta-analysis was based on 11 clinical studies between 1955 and 2007, and it included true placebo groups, used garlic-only preparations, and reported mean systolic and/or diastolic blood pressure (SBP/DBP) and standard deviations in their statistical analyses. This analysis concluded that individuals treated with garlic had better outcomes, and superior effects in lowering blood pressure in hypertensive individuals were observed compared with the placebo-treated group. The mean (SD) decrease in blood pressure reported in the hypertensive subgroup was 8.4 (2.8) mm Hg (n = 4; p < .001) for systolic and 7.3 (1.5) mm Hg for diastolic (n = 3; p < .001) blood pressure (Ried et al. 2008).

home remedies for diabetes 🔥how to home remedies for diabetes for 19.5.10. Ginkgo (Ginkgo biloba)

Ginkgo, a popular herbal remedy for centuries in China, has also become popular in Europe and America. One of the proposed indications has been to improve circulation. The focus of several studies has been to evaluate ginkgo leaf extract and measure the modulation of calcium levels in the endothelium and vasodilation (Chen et al. 2009). Ginkgo was reported to have a hypotensive effect in preclinical studies (Kubota et al. 2006a, 2006b; Koltermann et al. 2007). However, other studies have demonstrated that long term intake may not be useful (Tada et al. 2008). Clinical data have also suggested that ginkgo may lower blood pressure in healthy subjects over a treatment course of 3 months and within a single treatment for temporary stress-induced hypertension (Kudolo 2000; Jezova et al. 2002). However, controversy exists as other clinical studies have failed to confirm an effect (Chen et al. 2009).

19.5.11. I the 1 last update 2020/07/05 vyvy Ghome remedies for diabetes ☑how to home remedies for diabetes for ourd

Historically, ivy gourd was used in Ayurvedic medicine, a traditional East Indian healing system, to treat glycosuria. Reports suggest that active compounds in the plant may mimic the action of insulin and suppress the activity of certain enzymes involved in glucose production. Clinical research studies with ivy gourd extract have suggested its effect on fasting and postprandial blood glucose levels of the treated patient groups (Kuriyan et al. 2007).

19.5.12. Aloe (Aloe vera)

Aloe vera has also been used in the medicinal treatment of diabetes in India and the Arabian peninsula (Vogler and Ernst 1999; Evans 2003). The gel, which is obtained from the inner portion of the leaves, may contain glucomannan, a water-soluble fiber that reportedly has hypoglycemic and insulin-sensitizing actions (Vuksan et al. 1999, 2000). Preclinical studies have reported inconsistent results (Yeh et al. 2003). However, small-scale clinical research trials suggested an improvement in fasting glucose levels with the extract (Bunyapraphatsara et al. 1996; Yongchaiyudha et al. 1996; Yeh et al. 2003). In a comprehensive review of the effects of herbals on glycemia, Yeh et al. (2003) concluded that the preliminary data suggest a potential effect of Aloe vera in glycemic control; however, further validation is needed.

19.6. CONCLUSIONS

Botanical extracts have been widely used as medicinal agents throughout human history. Many are now available in commercial supplements and are promoted for general health benefits or for prevention and treatment of specific diseases. As such, the public’s interest in the potential benefit of botanical supplements on carbohydrate metabolism is quite high. The advantage of a botanical extract is that if botanicals are shown to be effective to improve metabolism and/or risk factors on a clinical level, these remedies, in general, are commonly available and therefore could potentially aid the general public with regard to obesity and diabetes. Unfortunately, although most of the popular botanicals have a long history in folk medicine, there is a paucity of definitive clinical data, particularly as it relates to consistently improving carbohydrate metabolism. There is insufficient evidence, based on currently available data, to actively recommend the use of any particular botanical product to treat either high blood glucose or other related risk factors. However, there are active investigations in many areas for which botanical preparations are consistent, and defined clinical studies are still ongoing. We need to await the results of these carefully conducted studies.

ACKNOWLEDGMENTS

This study is supported by P50AT002776-01 from the National Center for Complementary and Alternative Medicine and the Office of Dietary Supplements, which fund the botanical research center at Pennington Biomedical Research Center (LSU System) and Rutgers University.

REFERENCES

  1. Ahmad N, Hassan M.R, Halder H, Bennoor K.S. Effect of Momordica charantia (karolla) extracts on fasting andpostprandial serum glucose levels in NIDDM patients. Bangladesh Med Res Counc Bull. 1999;home remedies for diabetes ☑how to home remedies for diabetes for 25:11–3. [PubMed: 10758656]
  2. Ahmed I, Lakhani M.S, Gillett M, John A, Raza H. Hypotriglyceridemic and hypocholesterolemic effects of anti-diabetic Momordica charantia (karela) fruit extract in streptozotocin-induced diabetic rats. home remedies for diabetes 🔥how to home remedies for diabetes for Diabetes Res Clin Pract. 2001;51:155–61. [PubMed: 11269887]
  3. Al-Qattan K.K, Khan I, Alnaqeeb M.A, Ali M. Thromboxane-B2, prostaglandin-E2 and hypertension in the rat 2-kidney 1-clip model: A possible mechanism of the garlic induced hypotension. home remedies for diabetes ☑how to home remedies for diabetes for Prostaglandins Leukot Essent Fatty Acids. 2001;64:5–10. [PubMed: 11161580]
  4. Ali M, Al-Qattan K.K, Al-Enezi F, Khanafer R.M, Mustafa T. Effect of allicin from garlic powder on serum lipids and blood pressure in rats fed with ahigh cholesterol diet. Prostaglandins Leukot Essent Fatty Acids. 2000;home remedies for diabetes 🔴how to home remedies for diabetes for 62:253–9. [PubMed: 10882191]
  5. Altschuler J.A, Casella S.J, MacKenzie T.A, Curtis K.M. The effect of cinnamon on A1C among adolescents with type 1 diabetes. Diab Care. 2007;30:813–6. [PubMed: 17392542]
  6. Anderson R.A. Chromium and polyphenols from cinnamon improve insulin sensitivity. Proc Nutr Soc. 2008;67:48–53. [PubMed: 18234131]
  7. Anderson R.A, Broadhurst C.L, Polansky M.M, editors. Isolation and characterization of polyphenol type-A polymers from cinnamon with insulin-like biological activity. J Agric Food Chem. 2004;52:65–70. [PubMed: 14709014]
  8. Avula B, Wang Y.H, Pawar R.S, Shukla Y.J, Smillie T.J, Khan I.A. A rapid method for chemical fingerprint analysis of Hoodia species, related genera, and dietary supplementsusing UPLC- UV-MS. home remedies for diabetes ☑how to home remedies for diabetes for J Pharm Biomed Anal. 2008;48:722–31. [PubMed: 18718731]
  9. Basch E, Gabardi S, Ulbricht C. Bitter melon (Momordica charantia): A review of efficacy and safety. Am J the 1 last update 2020/07/05 Health Syst Pharm. 2003;60:356–9.Am J Health Syst Pharm. 2003;60:356–9. [PubMed: 12625217]
  10. Basch E, Ulbricht C, Kuo G, Szapary P, Smith M. Therapeutic applications of fenugreek. Altern Med Rev. 2003;8:20–7. [PubMed: 12611558]
  11. Baskaran K, Kizar Ahamath B, Radha Shanmugasundaram K, Shanmugasundaram E.R. Antidiabetic effect of a leaf extract from Gymnema sylvestre in non-insulin-dependent diabetesmellitus patients. J Ethnopharmacol. 1990;30:295–300. [PubMed: 2259217]
  12. Blevins S.M, Leyva M.J, Brown J, Wright J, Scofield R.H, Aston C.E. Effect of cinnamon on glucose and lipid levels in non insulin-dependent type 2 diabetes. Diab Care. 2007;30:2236–7. [PubMed: 17563345]
  13. Broca C, Gross R, Petit P, et al., editors. 4-hydroxyisoleucine: Experimental evidence of its insulinotropic and antidiabetic properties. Am J Physiol. 1999;277:E617–23. [PubMedhome remedies for diabetes 🔴how to home remedies for diabetes for : 10516120]
  14. Broca C, Manteghetti M, Gross R, et al., editors. 4-hydroxyisoleucine: Effects of synthetic and natural analogues on insulin secretion. Eur J Pharmacol. 2000;390:339–45. [PubMed: 10708743]
  15. Buettner C, Yeh G.Y, Phillips R.S, Mittleman M.A, Kaptchuk T.J. Systematic review of the effects of ginseng on cardiovascular risk factors. Ann Pharmacother. 2006;40:83–95. [PubMed: 16332943]
  16. Bunyapraphatsara N, Yongchaiyudha S, Rungpitarangsi V, Chokechaijaroenporn O. Antidiabetic activity of Aloe vera L juice. II. Clinical trial in diabetes mellitus patients in combination with glibenclamide. Phytomed. 1996;3:245–54. [PubMed: 23195078]
  17. Cefalu W.T. Insulin resistance: Cellular and clinical concepts. Exp Biol Med (Maywood). 2001;226:13–26. [PubMed: 11368233]
  18. Cefalu W.T, Ribnicky D.M. Modulation of insulin action by botanical therapeutics. Obes Weight the 1 last update 2020/07/05 Manag. Obes Weight Manag. 2009;5:277–81.
  19. Chaturvedi P. Role of Momordica charantia in maintaining the normal levels of lipids and glucose in diabetic rats fed a high-fat and low-carbohydrate diet. Br J for 1 last update 2020/07/05 Biomed Sci. 2005;62:124–6.Br J Biomed Sci. 2005;62:124–6. [PubMedhome remedies for diabetes ☑how to home remedies for diabetes for : 16196458]
  20. Chen Z.Y, Peng C, Jiao R, Wong Y.M, Yang N, Huang Y. Anti-hypertensive nutraceuticals and functional foods. J Agric Food Chem. 2009;57:4485–99. [PubMedhome remedies for diabetes 🔴how to home remedies for diabetes for : 19422223]
  21. Crawford P. Effectiveness of cinnamon for lowering hemoglobin A1C in patients with type 2 diabetes: A randomized, controlled trial. home remedies for diabetes ☑how to home remedies for diabetes for J for 1 last update 2020/07/05 Am Board Fam Med. J Am Board Fam Med. 2009;22:507–12. [PubMed: 19734396]
  22. Cruz C, Correa-Rotter R, Sanchez-Gonzalez D.J, et al., editors. Renoprotective and antihypertensive effects of S-allylcysteine in 5/6 nephrectomized rats. home remedies for diabetes 👍how to home remedies for diabetes for Am J Physiol Renal Physiol. 2007;293:F1691–8. [PubMed: 17686953]
  23. Cusi K, DeFronzo R.A. Metformin: A review of its metabolic effects. Diabetes Rev. 1998;6:89–131.
  24. Daisy P, Eliza J, Mohamed Farook K.A. A novel dihydroxy gymnemic triacetate isolated from Gymnema sylvestre possessing normoglycemic and hypolipidemic activity on STZ-induced diabetic rats. J Ethnopharmacol. 2009;126:339–44. [PubMed: 19703537]
  25. Dey L, Attele A.S, Yuan C.S. Alternative therapies for type 2 diabetes. home remedies for diabetes 🔴how to home remedies for diabetes for Altern Med Rev. 2002;home remedies for diabetes 👍how to home remedies for diabetes for 7:45–58. [PubMed: 11896745]
  26. Dugoua J.J, Seely D, Perri D, Cooley K, Forelli T, Mills E, Koren G. From type 2 diabetes to antioxidant activity: A systematic review of the safety and efficacy of common and cassia cinnamon bark. Can J Physiol Pharmacol. 2007;85:837–47. [PubMed: 18066129]
  27. El Kossori R.L, Villaume C, El Boustani E, Sauvaire Y, Mejean L. Composition of pulp, skin and seeds of prickly pears fruit (Opuntia ficus indica sp.). Plant Foods Hum Nutr. 1998;52:263–70. [PubMed: 9950087]
  28. Ennouri M, Fetoui H, Bourret E, Zeghal N, Guermazi F, Attia H. Evaluation of some biological parameters of Opuntia ficus indica.2. Influence of seed supplemented diet on rats. home remedies for diabetes ⭐️how to home remedies for diabetes for Bioresour Technol. 2006;97:2136–40. [PubMed: 16290138]
  29. Evans J.L. Diet, botanical, and nutritional treatments for type for 1 last update 2020/07/05 2 diabetes.Diet, botanical, and nutritional treatments for type 2 diabetes. 2003. http://www.endotext.com (accessed July 7, 2010)
  30. Fernandes N.P, Lagishetty C.V, Panda V.S, Naik S.R. An experimental evaluation of the antidiabetic and antilipidemic properties of a standardized Momordica charantia fruit extract. home remedies for diabetes 👍how to home remedies for diabetes for BMC Complement Altern Med. 2007;7:29. [PMC free article: PMC2048984] [PubMed: 17892543]
  31. Fernandez M.L, Lin E.C, Trejo A, McNamara D.J. Prickly pear (Opuntia spp.) pectin reverses low density lipoprotein receptor suppression induced by a hypercholesterolemic diet in guinea pigs. J Nutr. 1992;122:2330–40.J Nutr. 1992;122:2330–40. [PubMed: 1333520]
  32. Frati A.C, Gordillo B.E, Altamirano P, Ariza C.R, Cortes-Franco R, Chavez-Negrete A. Acute hypoglycemic effect of Opuntia streptacantha Lemaire in NIDDM. home remedies for diabetes 👍how to home remedies for diabetes for Diab Care. 1990;13:455–6. [PubMed for 1 last update 2020/07/05 : 2318110: 2318110]
  33. Gibson J.E, Taylor D.A. Can claims, misleading information and manufacturing issues regulating dietarysupplements be improved in the United States of America? J Pharmacol Exp for 1 last update 2020/07/05 Ther. J Pharmacol Exp Ther. 2005;314:939–44. [PubMed: 15833895]
  34. Ginestra G, Parker M.L, Bennett R.N, et al., editors. Anatomical, chemical, and biochemical characterization of cladodes from prickly pear [Opuntia ficus-indica (L.) Mill.] J Agric Food Chem. 2009;57:10323–30. [PubMed the 1 last update 2020/07/05 : 19831414: 19831414]
  35. Gopalpura P.B, Jayanthi C, Dubey S. Effect of Trigonella foenum-graecum seeds on the glycemic index of food: A clinical evaluation. Int J Diab Dev Ctries. 2009;27:41–5.
  36. Govorko D, Logendra S, Wang Y, editors. Polyphenolic compounds from Artemisia dracunculus L. inhibit PEPCK gene expression and gluconeogenesis in an H4IIE hepatoma cell line. home remedies for diabetes ☑how to home remedies for diabetes for Am J Physiol Endocrinol Metab. 2007;293:E1503–10. [PubMed: 17848630]
  37. Griggs B. Green Pharmacy: A History of Herbal Medicine. 1st ed. London: Robert Hale; 1981.
  38. Grover J.K, Rathi S.S, Vats V. Amelioration of experimental diabetic neuropathy and gastropathy in rats following oral administration of plant (Eugenia jambolana, Mucuna pruriens and Tinospora cordi- folia) extracts. Indian J Exp Biol. 2002;40:273–6. [PubMed: 12635695]
  39. Grover J.K, Vats V, Rathi S.S, Dawar R. Traditional Indian anti-diabetic plants attenuate progression of renal damage in streptozotocin induced diabetic mice. home remedies for diabetes 👍how to home remedies for diabetes for J Ethnopharmacol. 2001;76:233–8. [PubMed: 11448544]
  40. Grover J.K, Yadav S.P. Pharmacological actions and potential uses of Momordica charantia: A review. home remedies for diabetes 🔥how to home remedies for diabetes for J Ethnopharmacol. 2004; the 1 last update 2020/07/05 9393:123–32. [PubMed for 1 last update 2020/07/05 : 15182917: 15182917]
  41. Grover J.K, Yadav S, Vats V. Medicinal plants of India with anti-diabetic potential. J Ethnopharmacol. 2002;home remedies for diabetes 🔥how to home remedies for diabetes for 81:81–100. [PubMed: 12020931]
  42. Jarvill-Taylor K.J, Anderson R.A, Graves D.J. A hydroxychalcone derived from cinnamon functions as a mimetic for insulin in 3T3-L1 adipocytes. J Am Coll Nutr. 2001;20:327–36. [PubMedhome remedies for diabetes 🔴how to home remedies for diabetes for : 11506060]
  43. Jezova D, Duncko R, Lassanova M, Kriska M, Moncek F. Reduction of rise in blood pressure and cortisol release during stress by Ginkgo biloba extract (EGb 761) in healthy volunteers. J Physiol Pharmacol. 2002;home remedies for diabetes ⭐️how to home remedies for diabetes for 53:337–48. [PubMed for 1 last update 2020/07/05 : 12369732: 12369732]
  44. Jung M, Park M, Lee H.C, Kang Y.H, Kang E.S, Kim S.K. Antidiabetic agents from medicinal plants. Curr Med Chem. 2006; for 1 last update 2020/07/05 1313:1203–18. [PubMed: 16719780]
  45. Kassaian N, Azadbakht L, Forghani B, Amini A. Effect of fenugreek seeds on blood glucose and lipid profiles in type 2 diabetic patients. home remedies for diabetes ⭐️how to home remedies for diabetes for Int J Vitam Nutr Res. 2009;79:34–9. [PubMed: 19839001]
  46. Khan A, Safdar M, Ali Khan M.M, Khattak K.N, Anderson R.A. Cinnamon improves glucose and lipids of people with type 2 diabetes. Diab Care. 2003;26:3215–8. [PubMed: 14633804]
  47. Knowler W.C, Barrett-Connor E, Fowler S.E, Hamman R.F, Lachin J.M, Walker E.A, Nathan D.M. Diabetes Prevention Program Research Group. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. New Engl J Med. 2002; the 1 last update 2020/07/05 346346:393–403. [PMC free article: PMC1370926] [PubMed: 11832527]
  48. Koltermann A, Hartkorn A, Koch E, Furst R, Vollmar A.M, Zahler S. Ginkgo biloba extract EGb 761 increases endothelial nitric oxide production in vitro and in vivo. Cell the 1 last update 2020/07/05 Mol Life Sci. Cell Mol Life Sci. 2007;64:1715–22. [PubMed: 17497242]
  49. Ku D.D, Abdel-Razek T.T, Dai J, Kim-Park S, Fallon M.B, Abrams G.A. Garlic and its active metabolite allicin produce endothelium- and nitric oxide-dependent relaxation in rat pulmonary arteries. Clin Exp Pharmacol Physiol. 2002;29:84–91. [PubMed: 11906464]
  50. Krawinkel M.B, Keding G.B. Bitter gourd (Momordica charantia): A dietary approach to hyperglycemia. Nutr Rev. 2006;64:331–7. [PubMed the 1 last update 2020/07/05 : 16910221: 16910221]
  51. Kubota Y, Tanaka N, Kagota S, Nakamura K, Kunitomo M, Umegaki K, Shinozuka K. Effects of Ginkgo biloba extract on blood pressure and vascular endothelial response by acetylcholine in spontaneously hypertensive rats. home remedies for diabetes ⭐️how to home remedies for diabetes for J the 1 last update 2020/07/05 Pharm Pharmacol. J Pharm Pharmacol. 2006a;58:243–9. [PubMed for 1 last update 2020/07/05 : 16451753: 16451753]
  52. Kubota Y, Tanaka N, Kagota S, Nakamura K, Kunitomo M, Umegaki K, Shinozuka K. Effects of Ginkgo biloba extract feeding on salt-induced hypertensive Dahl rats. Biol Pharm Bull. 2006b;29:266–9. [PubMed: 16462029]
  53. Kudolo G.B. The effect of 3-month ingestion of Ginkgo biloba extract on pancreatic beta-cell function in response to glucose loading in normal glucose tolerant individuals. J Clin Pharmacol. 2000; for 1 last update 2020/07/05 4040:647–54. [PubMed: 10868316]
  54. Kuriyan R, Rajendran R, Bantwal G, Kurpad A.V. Effect of supplementation of Coccinia cordifolia extract on newly detected diabetic patients. home remedies for diabetes 🔥how to home remedies for diabetes for Diab Care. 2007;31:216–20. [PubMed: 18000183]
  55. Leach M.J. Gymnema sylvestre for diabetes mellitus: A systematic review. J Altern Complement Med. 2007;home remedies for diabetes 🔥how to home remedies for diabetes for 13:977–83. [PubMed: 18047444]
  56. Leung L, Birtwhistle R, Kotecha J, Hannah S, Cuthbertson S. Anti-diabetic and hypoglycemic effects of Momordica charantia (bitter melon): A mini review. Br J Nutr. 2009;102:1703–8. [PubMed: 19825210]
  57. Li C.Y, Cheng X.S, Cui M.Z, Yan Y.G. Regulative effect of Opuntia powder on blood lipidsin rats and its mechanism. Zhongguo Zhong Yao Za Zhi. 2005;30:694–6. [PubMed: 16075737]
  58. Logendra S, Ribnicky D.M, Yang H, Poulev A, Ma J, Kennelly E.J, Raskin I. Bioassay-guided isolation of aldose reductase inhibitors from Artemisia dracunculus. Phytochem. 2006;67:1539–46. [PubMed: 16806328]
  59. MacLean D.B, Luo L.G. Increased ATP content/production in the hypothalamus may be a signal for energy-sensing of satiety: Studies of the anorectic mechanism of a plant steroidal glycoside. Brain Red. 2004;1020:1–11.Brain Red. 2004;1020:1–11. [PubMed: 15312781]
  60. Mang B, Wolters M, Schmitt B, Kelb K, Lichtinghagen R, Stichtenoth D.O, Hahn A. Effects of a cinnamon extract on plasma glucose, HbA, and serum lipids in diabetes mellitus type 2. home remedies for diabetes ⭐️how to home remedies for diabetes for Eur J Clin Invest. 2006;36:340–4. [PubMed: 16634838]
  61. Marles R.J, Farnsworth N.R. Antidiabetic plants and their active constituents. Phytomed. 1995;2:137–89. [PubMed the 1 last update 2020/07/05 : 23196156: 23196156]
  62. Medina-Campos O.N, Barrera D, Segoviano-Murillo S, Rocha D, Maldonado P.D, Mendoza-Patino N, Pedraza-Chaverri J. S-allylcysteine scavenges singlet oxygen and hypochlorous acid and protects LLC-PK(1) cells of potassium dichromate-induced toxicity. Food Chem Toxicol. 2007;45:2030–9. [PubMedhome remedies for diabetes 🔥how to home remedies for diabetes for : 17576034]
  63. Neuhouser M.L. Dietary supplement use by American women: Challenges in assessing patterns of use, motives and costs. J Nutr. 2003;133:1992S–6S. [PubMed: 12771352]
  64. Oh P.S, Lim K.T. Glycoprotein (90 kDa) isolated from Opuntia ficus-indica var. saboten MAKINO lowers plasma lipid level through scavenging of intracellular radicals in Triton WR-1339-induced mice. Biol for 1 last update 2020/07/05 Pharm Bull. Biol Pharm Bull. 2006;29:1391–6. [PubMed: 16819175]
  65. Oubre A.Y, Carlson T.J, King S.R, Reaven G.M. From plant to patient: An ethnomedical approach to the identification of new drugs for the treatment of NIDDM. Diabetologia. 1997;40:614–7. [PubMed the 1 last update 2020/07/05 : 9165233: 9165233]
  66. Porchezhian E, Dobriyal R.M. An overview on the advances of Gymnema sylvestre: Chemistry, pharmacology and patents. Pharmazie. 2003;58:5–12. [PubMed: 12622244]
  67. Preuss H.G, Echard B, Polansky M.M, Anderson R. Whole cinnamon and aqueous extracts ameliorate sucrose-induced blood pressure elevations in spontaneouslyhypertensive rats. J Am Coll Nutr. 2006;25:144–50. [PubMed: 16582031]
  68. Rahman K, Lowe G.M. Garlic and cardiovascular disease: A critical review. J Nutr. 2006;136:736S–40S. [PubMed: 16484553]
  69. Ramkumar K.M, Vijayakumar R.S, Ponmanickam P, Velayuthaprabhu S, Archunan G, Rajaguru P. Antihyperlipidaemic effect of Gymnema montanum: A study on lipid profile and fatty acid composition in experimental diabetes. home remedies for diabetes 🔴how to home remedies for diabetes for Basic Clin for 1 last update 2020/07/05 Pharmacol Toxicol. 2008;103:538–45.Basic Clin Pharmacol Toxicol. 2008;103:538–45. [PubMed: 19067681]
  70. Rathi S.S, Grover J.K, Vats V. The effect of Momordica charantia and Mucuna pruriens in experimental diabetes and their effect on key metabolic enzymes involved in carbohydrate metabolism. Phytother Res. 2002; for 1 last update 2020/07/05 1616:236–43. [PubMedhome remedies for diabetes ⭐️how to home remedies for diabetes for : 12164268]
  71. Rathi S.S, Grover J.K, Vikrant V, Biswas N.R. Prevention of experimental diabetic cataractby Indian ayurvedic plant extracts. Phytother Res. 2002;16:774–7. [PubMed: 12458487]
  72. Ribnicky D.M, Poulev A, Watford M, Cefalu W.T, Raskin I. Antihyperglycemic activity of Tarralin, an ethanolic extract of Artemisia dracunculus L. Phytomed. 2006;13:550–7. [PubMedhome remedies for diabetes 👍how to home remedies for diabetes for : 16920509]
  73. Ribnicky D.M, Rood J, Raskin I, Poulev A, Cefalu W.T. In press. Plasma abundance of bioactives of Artemisia dracunculus L. are associated with enhanced insulin sensitivity in obese, insulin-resistant human subjects. J Compl Alt Med.
  74. Riddle M.C. Glycemic management of type 2 diabetes: An emerging strategy with oral agents, insulins, and combinations. Endocrinol Metab Clin North Am. 2005;34:77–98. [PubMed: 15752923]
  75. Ried K, Frank O.R, Stocks N.P, Fakler P, Sullivan T. Effect of garlic on blood pressure: A systematic review and meta-analysis. BMC Cardiovasc Disord. 2008;8:13. [PMC free article: PMC2442048] [PubMed: 18554422]
  76. Roman-Ramos R, Flores-Saenz J.L, Alarcon-Aguilar F.J. Anti-hyperglycemic effect of some edible plants. J Ethnopharmacol. 1995;48:25–32. [PubMed: 8569244]
  77. Shapiro K, Gong W.C. Natural products used for diabetes. home remedies for diabetes ☑how to home remedies for diabetes for J Am Pharm Assoc (Wash). 2002;42:217–26. [PubMed: 11926665]
  78. Sharifi A.M, Darabi R, Akbarloo N. Investigation of antihypertensive mechanism of garlic in 2K1C hypertensive rat. J Ethnopharmacol. 2003;86:219–24. [PubMed: 12738090]
  79. Shukla Y.J, Pawar R.S, Ding Y, Li X.C, Ferreira D, Khan I.A. Pregnane glycosides from Hoodia gordonii. Phytochem. 2009;70:675–83. [PubMed: 19303614]
  80. Srinivasan K. Fenugreek (trigonella foenum-graecum): A review of health beneficial physiological effects. Food Rev Internat. 2006;22:203–24.
  81. Tada Y, Kagota S, Kubota Y, Nejime N, Nakamura K, Kunitomo M, Shinozuka K. Long-term feeding of Ginkgo biloba extract impairs peripheral circulation and hepatic function in aged spontaneously hypertensive rats. Biol for 1 last update 2020/07/05 Pharm Bull. Biol Pharm Bull. 2008;31:68–72. [PubMed: 18175944]
  82. Vogler B.K, Ernst E. Aloe vera: A systematic review of its clinical effectiveness. Br J Gen for 1 last update 2020/07/05 Pract. 1999;49:823–8.Br J Gen Pract. 1999;49:823–8. [PMC free article: PMC1313538] [PubMed: 10885091]
  83. Vogler B.K, Pittler M.H, Ernst E. The efficacy of ginseng: A systematic review of randomised clinicaltrials. Eur J Clin Pharmacol. 1999;55:567–75. [PubMedhome remedies for diabetes 🔥how to home remedies for diabetes for : 10541774]
  84. Vuksan V, Jenkins D. J. A, Spadafora P, editors. Konjac-mannan (glucomannan) improves glycemia and other associated risk factors for coronary heart disease in type 2 diabetes: A randomized controlled metabolic trial. Diab Care. 1999;22:913–9. [PubMed: 10372241]
  85. Vuksan V, Sievenpiper J.L, Owen R, editors. Beneficial effects of viscous dietary fiber from Konjac- mannan in subjects with the insulin resistance syndrome: Results of a controlled metabolic trial. Diab Care. 2000;23:9–14. [PubMed: 10857960]
  86. Wang Z.Q, Ribnicky D, Zhang X.H, Raskin I, Yu Y, Cefalu W.T. Bioactives of Artemisia dracunculus L enhance cellular insulin signaling in primary human skelmuscle culture. Metabolism. 2008;57:S58–64. [PMC free article: PMC2981033] [PubMed: 18555856]
  87. Wang Z.Q, Ribnicky D, Zhang X.H, Zuberi A, Raskin I, Yu Y, Cefalu W.T. An extract of Artemisia dracunculus L. enhances insulin receptor signaling and modulates gene expression in skelmuscle in KK-A(y) mice. J for 1 last update 2020/07/05 Nutr Biochem. J Nutr Biochem. 2010;22(1):71–8.J for 1 last update 2020/07/05 Nutr Biochem. J Nutr Biochem. 2010;22(1):71–8. 2011 Jan. [PMC free article: PMC4020631] [PubMed the 1 last update 2020/07/05 : 20447816: 20447816]
  88. Wolfram R.M, Kritz H, Efthimiou Y, Stomatopoulos J, Sinzinger H. Effect of prickly pear (Opuntia robusta) on glucose- and lipid-metabolism in nondiabetics with hyperlipidemia: A pilot study. Wien for 1 last update 2020/07/05 Klin Wochenschr. 2002;114:840–6.Wien Klin Wochenschr. 2002;114:840–6. [PubMed for 1 last update 2020/07/05 : 12503475: 12503475]
  89. Yeh G.Y, Eisenberg D.M, Kaptchuk T.J, Phillips R.S. Systematic review of herbs and dietary supplements for glycemic control in diabetes. Diab Care. 2003;26:1277–94. [PubMed: 12663610]
  90. Yongchaiyudha S, Rungpitarangsi V, Bunyapraphatsara N, Chokechaijaroenporn O. Antidiabetic activity of Aloe vera L. juice. I. Clinical trial in new cases of diabetes mellitus. Phytomed. 1996;3:241–3. [PubMed: 23195077]
  91. Ziegenfuss T.N, Hofheins J.E, Mendel R.W, Landis J, Anderson R.A. Effects of a water-soluble cinnamon extract on body composition and features of the metabolic syndrome in pre-diabetic men and women. J Int Soc Sports Nutr. 2006;3:45–53. [PMC free article: PMC2129164] [PubMed: 18500972]
Copyright © 2011 by Taylor and Francis Group, LLC.
Bookshelf ID: NBK92755PMID: 22593924

Views

  • PubReader
  • Print View
  • Cite this Page
    Cefalu WT, Stephens JM, Ribnicky DM. Diabetes and Herbal (Botanical) Medicine. In: Benzie IFF, Wachtel-Galor S, editors. Herbal Medicine: Biomolecular and Clinical Aspects. 2nd edition. Boca Raton (FL): CRC Press/Taylor & Francis; 2011. Chapter 19.

home remedies for diabetes ☑how to home remedies for diabetes for Related information

  • PMC
    PubMed Central citations
  • PubMed
    Links to PubMed

home remedies for diabetes 🔥how to home remedies for diabetes for Similar articles in PubMed

See reviews...See all...

home remedies for diabetes 👍how to home remedies for diabetes for Recent Activity

Your browsing activity the 1 last update 2020/07/05 is empty.Your browsing activity is empty.

Activity recording is turned off.

home remedies for diabetes 👍how to home remedies for diabetes for Turn recording back on

See more...
External link. Please review our privacy policy.

National Center for Biotechnology Information, U.S. National Library of Medicine home remedies for diabetes 🔥how to home remedies for diabetes for 8600 Rockville Pike, Bethesda MD, the 1 last update 2020/07/05 2089420894 USA

Policies and Guidelines | Contact